Microscale crystallization is at the frontier of chemical engineering, material science, and biochemical research and is affected by many factors. The precise regulation and control of microscale crystal processes is still a major challenge. In the heterogeneous induced nucleation process, the chemical and micro/nanostructural characteristics of the interface play a dominant role. Ideal crystal products can be obtained by modifying the interface characteristics, which has been proven to be a promising strategy. This review illustrates the application of interface properties, including chemical characteristics (hydrophobicity and functional groups) and the morphology of micro/nanostructures (rough structure and cavities, pore shape and pore size, surface porosity, channels), in various microscale crystallization controls and process intensification. Finally, possible future research and development directions are outlined to emphasize the importance of interfacial crystallization control and regulation for crystal engineering.

微尺度结晶处于化学工程、材料科学和生化研究的前沿，受多种因素影响。微尺度晶体工艺的精确调控仍然是一个重大挑战。在异质诱导成核过程中，界面的化学和微/纳米结构特征起主导作用。通过改变界面特性可以获得理想的晶体产品，这已被证明是一种很有前途的策略。这篇综述阐述了界面特性在各种微尺度结晶控制和过程中的应用，包括化学特性（疏水性和官能团）和微/纳米结构的形态（粗糙结构和空腔、孔形状和孔径、表面孔隙率、通道）集约化。