Accumulating evidence demonstrates that the oral pathobiont Fusobacterium nucleatum is involved in the progression of an increasing number of tumors types. Thus far, the mechanisms underlying tumor exacerbation by F. nucleatum include the enhancement of proliferation, establishment of a tumor-promoting immune environment, induction of chemoresistance, and the activation of immune checkpoints. This review focuses on the mechanisms that mediate tumor-specific colonization by fusobacteria. Elucidating the mechanisms mediating fusobacterial tumor tropism and promotion might provide new insights for the development of novel approaches for tumor detection and treatment.

中文翻译：

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具核梭杆菌与癌症

越来越多的证据表明，口腔致病菌具核梭杆菌参与了越来越多的肿瘤类型的进展。迄今为止，具核梭菌引起肿瘤恶化的机制包括促进增殖、建立促进肿瘤的免疫环境、诱导化学抗性和激活免疫检查点。这篇综述的重点是通过梭杆菌介导肿瘤特异性定植的机制。阐明介导梭杆菌肿瘤趋向性和促进作用的机制可能为开发新的肿瘤检测和治疗方法提供新的见解。