A regioselective [3+3] annulation of alkynyl ketimines with α-cyano ketones for the synthesis of polysubstituted 4H-pyran derivatives with a quaternary CF₃-containing center has been realized by using Cu(OAc)₂ as a catalyst, providing the desired products in up to 99 % yield. The method tolerates some variations in the α-CF₃ alkynyl ketimines and α-cyano ketones scope. The products could be synthesized on a gram-scale and several products were conveniently transformed.

中文翻译：

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铜催化的区域选择性 [3+3] 炔基酮亚胺与 α-氰基酮的环化：具有含 CF3 季铵中心的多取代 4H-吡喃衍生物的合成

通过使用 Cu(OAc) ₂作为催化剂，实现了炔基酮亚胺与α-氰基酮的区域选择性 [3+3] 环化，用于合成具有含季 CF ₃中心的多取代 4 H-吡喃衍生物，提供了所需产品的收率高达 99%。该方法容许α- CF ₃炔基酮亚胺和α-氰基酮范围的一些变化。这些产品可以以克级合成，并且可以方便地转化几种产品。