Adaptive aberrant gene regulation is a hallmark of malignant growth and therapy resistance in acute myeloid leukemia (AML). In this issue of Cell Stem Cell, Eagle et al. identified oncogenic enhancer-driven overexpression of selenophosphate synthetase 2 (SEPHS2) as an opportunity for targeted mitigation of malignant cell growth in AML.

中文翻译：

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SEPH防护急性髓系白血病

适应性异常基因调控是急性髓性白血病 (AML) 恶性生长和治疗抵抗的标志。在本期Cell Stem Cell中，Eagle 等人。确定致癌增强子驱动的硒磷酸合成酶2（SEPHS2）过表达是靶向缓解AML中恶性细胞生长的机会。