For a century, since the pioneering work of Otto Warburg, the interwoven relationship between metabolism and cancer has been appreciated. More recently, with obesity rates rising in the U.S. and worldwide, epidemiologic evidence has supported a link between obesity and cancer. A substantial body of work seeks to mechanistically unpack the association between obesity, altered metabolism, and cancer. Without question, these relationships are multifactorial and cannot be distilled to a single obesity- and metabolism-altering hormone, substrate, or factor. However, it is important to understand the hormone-specific associations between metabolism and cancer. Here, we review the links between obesity, metabolic dysregulation, insulin, and cancer, with an emphasis on current investigational metabolic adjuncts to standard-of-care cancer treatment.

中文翻译：

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胰岛素与癌症：一张错综复杂的网

一个世纪以来，自 Otto Warburg 的开创性工作以来，新陈代谢与癌症之间的交织关系得到了重视。最近，随着美国和全世界肥胖率的上升，流行病学证据支持肥胖与癌症之间存在联系。大量工作试图从机制上解开肥胖、新陈代谢改变和癌症之间的关联。毫无疑问，这些关系是多因素的，不能归结为单一的肥胖和代谢改变激素、底物或因素。然而，重要的是要了解新陈代谢与癌症之间的激素特异性关联。在这里，我们回顾了肥胖、代谢失调、胰岛素和癌症之间的联系，重点是目前研究中的代谢辅助癌症治疗标准。