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SARS-CoV-2 Detection Using Colorimetric Plasmonic Sensors: A Proof-of-Concept Computational Study
IEEE Transactions on NanoBioscience ( IF 3.9 ) Pub Date : 2022-03-02 , DOI: 10.1109/tnb.2022.3156077
Somen Baidya , Ahmed M. Hassan

Traditional molecular techniques for SARS-CoV-2 viral detection are time-consuming and can exhibit a high probability of false negatives. In this work, we present a computational study of SARS-CoV-2 detection using plasmonic gold nanoparticles. The resonance wavelength of a SARS-CoV-2 virus was recently estimated to be in the near-infrared region. By engineering gold nanospheres to specifically bind with the outer surface of the SARS-CoV-2 virus, the resonance frequency can be shifted to the visible range (380 nm–700 nm). Moreover, we show that broadband absorption will emerge in the visible spectrum when the virus is partially covered with gold nanoparticles at a specific coverage percentage. This broadband absorption can be used to guide the development of an efficient and accurate colorimetric plasmon sensor for COVID-19 detection. Our observation also suggests that this technique is unaffected by the number of protein spikes present on the virus outer surface, hence can pave a potential path for a label-free COVID-19 diagnostic tool independent of the number of protein spikes.

中文翻译:

使用比色等离子体传感器检测 SARS-CoV-2:一项概念验证计算研究

用于 SARS-CoV-2 病毒检测的传统分子技术非常耗时,并且很可能会出现假阴性。在这项工作中,我们提出了使用等离子体金纳米粒子检测 SARS-CoV-2 的计算研究。最近估计 SARS-CoV-2 病毒的共振波长在近红外区域。通过设计金纳米球与 SARS-CoV-2 病毒的外表面特异性结合,共振频率可以转移到可见光范围 (380 nm–700 nm)。此外,我们表明,当病毒以特定覆盖率被金纳米粒子部分覆盖时,可见光谱中会出现宽带吸收。这种宽带吸收可用于指导开发用于 COVID-19 检测的高效、准确的比色等离子体传感器。
更新日期:2022-03-02
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