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Interpregnancy interval and the risk of oppositional defiant disorder in offspring
Development and Psychopathology ( IF 5.317 ) Pub Date : 2022-03-02 , DOI: 10.1017/s095457942200013x
Berihun Assefa Dachew 1 , Gavin Pereira 1, 2, 3 , Gizachew Assefa Tessema 1, 4 , Gursimran Kaur Dhamrait 2, 5 , Rosa Alati 1, 6
Affiliation  

The study aimed to investigate the association between interpregnancy interval (IPI) and parent-reported oppositional defiant disorder (ODD) in offspring at 7 and 10 years of age. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing population-based longitudinal study based in Bristol, United Kingdom (UK). Data included in the analysis consisted of more than 3200 mothers and their singleton children. The association between IPI and ODD was determined using a series of log-binomial regression analyses. We found that children of mothers with short IPI (<6 months) were 2.4 times as likely to have a diagnosis of ODD at 7 and 10 years compared to mothers with IPI of 18–23 months (RR = 2.45; 95%CI: 1.24–4.81 and RR = 2.40; 95% CI: 1.08–5.33), respectively. We found no evidence of associations between other IPI categories and risk of ODD in offspring in both age groups. Adjustment for a wide range of confounders, including maternal mental health, and comorbid ADHD did not alter the findings. This study suggests that the risk of ODD is higher among children born following short IPI (<6 months). Future large prospective studies are needed to elucidate the mechanisms explaining this association.



中文翻译:

妊娠间隔和后代对立违抗障碍的风险

该研究旨在调查妊娠间隔 (IPI) 与父母报告的 7 岁和 10 岁后代的对立违抗障碍 (ODD) 之间的关联。我们使用了雅芳父母和儿童纵向研究 (ALSPAC) 的数据,这是一项位于英国布里斯托尔正在进行的基于人群的纵向研究。分析中包含的数据包括 3200 多名母亲及其独生子女。IPI 和 ODD 之间的关联是通过一系列对数二项式回归分析确定的。我们发现,与 IPI 为 18-23 个月的母亲相比,IPI 较短(<6 个月)的母亲的孩子在 7 岁和 10 岁时被诊断为 ODD 的可能性是 2.4 倍(RR = 2.45;95%CI:1.24) –4.81 和 RR = 2.40;95% CI:1.08–5.33)。我们没有发现任何证据表明其他 IPI 类别与两个年龄组后代的 ODD 风险之间存在关联。对一系列混杂因素(包括孕产妇心理健康和共病多动症)的调整并没有改变研究结果。这项研究表明,短期 IPI(<6 个月)出生的孩子患 ODD 的风险较高。未来需要进行大型前瞻性研究来阐明解释这种关联的机制。

更新日期:2022-03-02
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