Purpose

Viburnum opulus L. fruits have been used in traditional medicine in the Turkish population for kidney problems, hypoglycemic and cough relaxant activities. This study aimed to prepare V. opulus extract-loaded orally disintegrating films (ODFs) to enhance oral absorption and improve patient compliance.

Methods

ODF formulations were prepared using the solvent casting method. Carboxymethyl cellulose (0.5%, 1%, 1.5% w/w) and chitosan (0.5%, 1%, 1.5% w/w) were selected as film-forming polymers and glycerol was utilized as a plasticizer. Chlorogenic acid is the major metabolite of V. opulus fruits. The chlorogenic acid content in formulations and the plant extract was measured using high-performance thin-layer chromatography (HPTLC). Characterization studies on the formulations such as elongation at break, tensile strength, Young’s modulus, DSC, SEM, and FT-IR were conducted. Bioadhesion, in vitro disintegration, and in vitro release studies were performed.

Results

Desired mechanical and morphological properties were obtained for ODFs. Disintegration times (15.38 ± 0.88 s) and release studies (85.19% at 30 min) showed that the 0.5% chitosan films were the most convenient formulation for delivering V. opulus extract.

Conclusion

ODFs were evaluated as a smart delivery route for phytochemicals avoiding any gastrointestinal effects and enhancing oral absorption.

中文翻译：

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Viburnum opulus L. 提取物的口腔分散薄膜的开发和表征：植物化学物质的潜在给药途径

目的

Viburnum opulus L. 果实已在土耳其人群中用于治疗肾脏问题、降血糖和止咳活动的传统医学。本研究旨在制备装载V. opulus提取物的口腔崩解膜 (ODF)，以增强口腔吸收并提高患者的依从性。

方法

ODF 配方是使用溶剂浇铸法制备的。选择羧甲基纤维素（0.5%、1%、1.5% w/w）和壳聚糖（0.5%、1%、1.5% w/w）作为成膜聚合物，并使用甘油作为增塑剂。绿原酸是V. opulus果实的主要代谢物。使用高效薄层色谱法 (HPTLC) 测量制剂和植物提取物中的绿原酸含量。对断裂伸长率、拉伸强度、杨氏模量、DSC、SEM 和 FT-IR 等配方进行了表征研究。进行了生物粘附、体外崩解和体外释放研究。

结果

获得了 ODF 所需的机械和形态特性。崩解时间 (15.38 ± 0.88 s) 和释放研究 (85.19% 在 30 分钟) 表明 0.5% 壳聚糖薄膜是最方便的输送V. opulus提取物的配方。

结论

ODF 被评估为植物化学物质的智能递送途径，可避免任何胃肠道影响并增强口服吸收。