The accumulation of misfolded or otherwise unwanted proteins in a cell, known as proteotoxic stress, triggers an inflammatory response. This study describes a role for PKR as the sensor of protein accumulation, which triggers an innate immune response and helps to restore homeostasis.

中文翻译：

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感知蛋白毒性压力

细胞中错误折叠或其他不需要的蛋白质的积累，称为蛋白毒性应激，会引发炎症反应。这项研究描述了 PKR 作为蛋白质积累传感器的作用，它触发先天免疫反应并有助于恢复体内平衡。