An increasing number of noncoding RNAs (ncRNAs) have been found to regulate gene expression and protein functions, playing important roles in diverse biological processes and diseases. Their crucial functions have been reported in almost every cell type and all stages of skin wound healing. Evidence of their pathogenetic roles in common wound complications, such as chronic nonhealing wounds and excessive scarring, is also accumulating. Given their unique expression and functional properties, ncRNAs are promising therapeutic and diagnostic entities. In this review, we discuss current knowledge about the functional roles of noncoding elements, such as microRNAs, long ncRNAs, and circular RNAs, in skin wound healing, focusing on in vivo evidence from studies of human wound samples and animal wound models. Finally, we provide a perspective on the outlook of ncRNA-based therapeutics in wound care.

中文翻译：

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超越密码：皮肤伤口愈合中的非编码 RNA

越来越多的非编码 RNA (ncRNA) 被发现可以调节基因表达和蛋白质功能，在多种生物过程和疾病中发挥重要作用。几乎所有细胞类型和皮肤伤口愈合的所有阶段都报告了它们的关键功能。关于它们在常见伤口并发症中的致病作用的证据，例如慢性不愈合伤口和过度疤痕，也在不断积累。鉴于其独特的表达和功能特性，ncRNA 是有前途的治疗和诊断实体。在这篇综述中，我们讨论了关于非编码元件（如 microRNA、长 ncRNA 和环状 RNA）在皮肤伤口愈合中的功能作用的当前知识，重点关注来自人类伤口样本和动物伤口模型研究的体内证据。最后，