Abstract

Introduction Although nephroblastomas are frequently treated without prior biopsy, there are the occasional other pediatric renal tumors that require different management. In the literature, there are around 30 primary renal germ cell tumors (GCT), including four cases of Yolk sac tumor (YST). We present another primary renal YST.Case report: A five-year-old boy was diagnosed as Wilms tumor on radiology and needle biopsy. He received chemotherapy, with no response. The post-chemotherapy resection specimen revealed a YST.Conclusion: Renal YST may be indistinguishable from Wilms tumor clinically and radiologically. For pre-biopsy chemotherapy management protocols, serum tumor markers such as AFP may be recommended to identify the occasional GCT, including YST. Pre-chemotherapy needle biopsies may lead to misdiagnosis, and may require confirmation by an experienced pathologist or central review.

摘要

简介尽管肾母细胞瘤通常无需事先进行活检即可进行治疗，但偶尔也会有其他儿童肾肿瘤需要不同的处理。在文献中，大约有 30 例原发性肾生殖细胞肿瘤 (GCT)，其中包括 4 例卵黄囊瘤 (YST)。我们提出另一种原发性肾脏 YST。病例报告：一名五岁男孩经放射学和穿刺活检诊断为肾母细胞瘤。他接受了化疗，但没有任何反应。化疗后切除标本显示 YST。结论：肾 YST 在临床和放射学上可能与 Wilms 肿瘤无法区分。对于活检前化疗管理方案，可能建议使用血清肿瘤标志物（如 AFP）来识别偶发的 GCT，包括 YST。化疗前穿刺活检可能会导致误诊，可能需要有经验的病理学家或中央审查人员进行确认。