Acetyl-coenzyme A is an important metabolite and regulates diverse cellular processes, including metabolism and epigenetics. In this issue of Cell Chemical Biology, Summers et al. (2022) describe an essential parasite enzyme, acetyl-coenzyme A synthetase, as a target of two antimalarial small molecules active against liver and blood stages of the parasite.

中文翻译：

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没有乙酰辅酶A可以阻止疟原虫

乙酰辅酶 A 是一种重要的代谢物，可调节多种细胞过程，包括代谢和表观遗传学。在本期细胞化学生物学中，萨默斯等人。(2022) 描述了一种必需的寄生虫酶，乙酰辅酶 A 合成酶，作为两种抗疟小分子的靶标，这些小分子对寄生虫的肝脏和血液阶段具有活性。