Chronic wounds (e.g. diabetic wounds, pressure wounds, vascular ulcers, etc.) do not usually heal in a timely and orderly manner but rather last for years and may lead to irreversible adverse events, resulting in a substantial financial burden for patients and society. Recently, a large amount of evidence has proven that cellular senescence has a crucial influence on chronic nonhealing wounds. As a defensive mechanism, cell senescence is a manner of cell-cycle arrest with increased secretory phenotype to resist death, preventing cells from stress-induced damage in cancer and noncancer diseases. A growing amount of research has advanced the perception of cell senescence in various chronic wounds and focuses on pathological and physiological processes and therapies targeting senescent cells. However, previous reviews have failed to sum up novel understandings of senescence in chronic wounds and emerging strategies targeting senescence. Herein, we discuss the characteristics and mechanisms of cellular senescence and the link between senescence and chronic wounds as well as some novel antisenescence strategies targeting other diseases that may be applied for chronic wounds.

中文翻译：

---

慢性伤口的衰老和潜在的靶向治疗

慢性伤口（如糖尿病伤口、压力性伤口、血管溃疡等）通常不会及时、有序地愈合，而是持续数年，并可能导致不可逆转的不良事件，给患者和社会带来巨大的经济负担。最近，大量证据证明细胞衰老对慢性不愈合伤口具有至关重要的影响。作为一种防御机制，细胞衰老是一种细胞周期停滞的方式，具有增加的分泌表型以抵抗死亡，防止细胞在癌症和非癌症疾病中受到压力诱导的损伤。越来越多的研究推动了对各种慢性伤口中细胞衰老的认识，并专注于针对衰老细胞的病理和生理过程和疗法。然而，以前的评论未能总结对慢性伤口衰老的新认识以及针对衰老的新兴策略。在此，我们讨论了细胞衰老的特征和机制，以及衰老与慢性伤口之间的联系，以及一些针对其他疾病的新抗衰老策略，这些策略可能适用于慢性伤口。