Histological evidence of osteodystrophy and osteopenia is encountered in most patients who have undergone successful renal transplantation. Renal transplantation may be beneficial for correcting uremia-related problems in end-stage renal disease patients; however, its benefit is limited in bone metabolism disorders. The present study aims to evaluate bone mass measurements and investigate the influencing factors in patients with renal transplant. One hundred and eighteen patients (83 males and 35 females) with a mean age of 40.2 ± 11.8 yr (range 20-67) were included in the present study. The laboratory and the clinical data of the patients were retrospectively analyzed. The association between bone mineral density (BMD) measurements and the demographic characteristics of the patients, serum creatinine, parathormone, calcium, phosphorous, alkaline phosphatase, 25-hydroxyvitamin D and the glomerular filtration rate were evaluated. Of the patients, 23.7% (n =28) had normal, 48.3% (n = 57) had osteopenic and 28% (n = 33) had osteoporotic BMD values. A significant positive correlation was determined between the body mass index (BMI) and the BMD measurement results (p = 0.001; r = 0.385). A negative correlation was determined between the BMD values and the serum parathormone (p = 0.012; r = -0.237). BMD values were significantly lower in the group that had not received mammalian target of rapamycin (mTOR) inhibitor (p = 0.026).

Conclusion: BMI values, mTOR inhibitor treatment and serum parathormone levels had an effect on the BMD measurement values.

大多数成功进行肾移植的患者都会遇到骨营养不良和骨质减少的组织学证据。肾移植可能有助于纠正终末期肾病患者的尿毒症相关问题；然而，它的益处仅限于骨代谢障碍。本研究旨在评估骨量测量并调查肾移植患者的影响因素。本研究包括 118 名患者（83 名男性和 35 名女性），平均年龄为 40.2 ± 11.8 岁（范围 20-67 岁）。对患者的实验室及临床资料进行回顾性分析。骨矿物质密度 (BMD) 测量值与患者的人口统计学特征、血清肌酐、甲状旁腺素、钙、磷、碱性磷酸酶、25-羟基维生素 D 和评估肾小球滤过率。在这些患者中，23.7% (n = 28) 正常，48.3% (n = 57) 有骨质减少和 28% (n = 33) 有骨质疏松 BMD 值。体重指数 (BMI) 与 BMD 测量结果之间存在显着的正相关关系( p = 0.001; r = 0.385)。BMD 值与血清甲状旁腺素呈负相关（p = 0.012；r = -0.237）。未接受哺乳动物雷帕霉素靶蛋白 (mTOR) 抑制剂组的 BMD 值显着降低 (p = 0.026)。

结论：BMI值、mTOR抑制剂治疗和血清甲状旁腺素水平对BMD测量值有影响。