Yang, Zhang, Luan et al. report that a germline variant that increases the risk of Philadelphia chromosome-like acute lymphoblastic leukaemia upregulates GATA3 expression, which changes chromatin accessibility to allow activation of oncogenic pathways.

中文翻译：

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将种系变异与白血病发病机制联系起来

杨，张，栾等。报告说，增加费城染色体样急性淋巴细胞白血病风险的种系变异上调 GATA3 表达，这会改变染色质的可及性以激活致癌途径。