当前位置: X-MOL 学术Prog. Retin. Eye. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
It is time for a moonshot to find “Cures” for diabetic retinal disease
Progress in Retinal and Eye Research ( IF 17.8 ) Pub Date : 2022-02-11 , DOI: 10.1016/j.preteyeres.2022.101051
S Robert Levine 1 , Przemyslaw Sapieha 2 , Sanjoy Dutta 3 , Jennifer K Sun 4 , Thomas W Gardner 5
Affiliation  

Diabetic retinal disease (DRD), the most common complication of diabetes and a leading cause of blindness in working age individuals, is now understood to be a form of sensory neuropathy or neurovascular degeneration. Current treatments are focused on advanced vision-threatening disease and a single molecular target, vascular endothelial growth factor, has an approved therapy. We trace the evolution of understanding of DRD pathogenesis, identify new approaches to clinical assessment, trials infrastructure and design, and target identification to accelerate selection and evaluation of new therapeutics that will speed development of potentially curative interventions. Critically, the “Restoring Vision Moonshot” framework will address gaps in knowledge to be filled to achieve the goal of restoring sight and preventing vision loss in persons with diabetes.



中文翻译:

是时候为糖尿病视网膜疾病寻找“治愈方法”了

糖尿病视网膜疾病 (DRD) 是糖尿病最常见的并发症,也是工作年龄个体失明的主要原因,现在被认为是感觉神经病变或神经血管变性的一种形式。目前的治疗主要针对危及视力的晚期疾病,而单一分子靶点血管内皮生长因子已获得批准。我们追踪对 DRD 发病机制理解的演变,确定临床评估的新方法、试验基础设施和设计以及目标识别,以加速新疗法的选择和评估,从而加速潜在治愈性干预措施的开发。至关重要的是,

更新日期:2022-02-11
down
wechat
bug