Background. Fibroblast growth factor 21 (FGF-21) is a hormone that regulates glucose and lipid metabolism. High serum FGF-21 levels are associated with carotid atherosclerosis and coronary artery disease. This cross-sectional study aimed to assess the relationship between serum FGF-21 levels and carotid-femoral pulse wave velocity (cfPWV) in patients on maintenance hemodialysis (HD). Methods. Blood samples and baseline characteristics were collected from 130 HD patients. Serum FGF-21 concentrations were measured with an enzyme-linked immunosorbent assay kit. Aortic stiffness was defined as a carotid-femoral pulse wave velocity (cfPWV) of more than 10 m/s. Results. Of the 130 HD patients, aortic stiffness was diagnosed in 54 (41.5%). Serum FGF-21 levels were significantly higher in those with aortic stiffness than those without . The FGF-21 level was independently associated with aortic stiffness (odds ratio (OR): 1.008; 95% CI: 1.003–1.012; ) after adjusting for diabetes mellitus, age, hypertension, C-reactive protein, and body weight in multivariable logistic regression analysis. Multivariable forward stepwise linear regression analysis also confirmed that the logarithmically transformed FGF-21 level (β = 3.245, 95% CI: 1.593–4.987, ) was an independent predictor of cfPWV values. The area under the receiver operating characteristic (ROC) curve predicting aortic stiffness by the serum FGF-21 level was 0.693 (95% CI: 0.606–0.771, ). Conclusions. Serum FGF-21 level positively correlates with cfPWV and is also an independent predictor of aortic stiffness in maintenance HD patients.

中文翻译：

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血清成纤维细胞生长因子 21 水平与维持性血液透析患者的主动脉僵硬有关

背景。成纤维细胞生长因子 21 (FGF-21) 是一种调节葡萄糖和脂质代谢的激素。高血清 FGF-21 水平与颈动脉粥样硬化和冠状动脉疾病有关。这项横断面研究旨在评估维持性血液透析 (HD) 患者血清 FGF-21 水平与颈股动脉脉搏波速度 (cfPWV) 之间的关系。方法。收集了 130 名 HD 患者的血样和基线特征。用酶联免疫吸附测定试剂盒测量血清 FGF-21 浓度。主动脉僵硬度定义为颈股动脉脉搏波速度 (cfPWV) 超过 10 m/s。结果. 在 130 名 HD 患者中，54 名 (41.5%) 被诊断为主动脉僵硬。主动脉僵硬患者的血清 FGF-21 水平显着高于无主动脉僵硬患者. FGF-21 水平与主动脉僵硬独立相关（优势比 (OR)：1.008；95% CI：1.003–1.012；)在多变量逻辑回归分析中调整糖尿病、年龄、高血压、C 反应蛋白和体重后。多变量前向逐步线性回归分析也证实了对数转换后的 FGF-21 水平 ( β  = 3.245, 95% CI: 1.593–4.987,)是 cfPWV 值的独立预测因子。通过血清 FGF-21 水平预测主动脉僵硬度的受试者工作特征 (ROC) 曲线下面积为 0.693 (95% CI: 0.606–0.771,）。 结论。血清 FGF-21 水平与 cfPWV 呈正相关，也是维持性 HD 患者主动脉僵硬度的独立预测因子。