This study investigated how serum testosterone related to frailty in ageing male C57Bl/6 mice with or without lifelong testosterone deficiency. Mice underwent a sham surgery (n = 10) or gonadectomy (n = 11, GDX) at 4-weeks and then aged. Frailty scores (31-item frailty index) and testosterone were measured between 18- to 24-months of age. Age predicted frailty (p < 0.0001), but serum testosterone did not (p = 0.357). Life expectancy (AFRAID clock) and biologic age (FRIGHT clock) were not significantly different between groups (p = 0.485 and 0.142). The fact that lifelong testosterone deficiency did not exacerbate frailty suggests that low testosterone alone does not potently drive frailty in males.

这项研究调查了血清睾酮如何与老年雄性 C57Bl/6 小鼠的虚弱相关，无论是否存在终生睾酮缺乏症。小鼠在 4 周时接受了假手术 (n = 10) 或性腺切除术 (n = 11, GDX)，然后老化。虚弱评分（31 项虚弱指数）和睾酮在 18 至 24 个月大之间进行测量。年龄预测虚弱（p < 0.0001），但血清睾酮没有（p = 0.357）。各组之间的预期寿命（AFRAID 时钟）和生物学年龄（FRIGHT 时钟）没有显着差异（p = 0.485 和 0.142）。终生睾酮缺乏并没有加剧虚弱的事实表明，单独的低睾酮并不能有效地导致男性虚弱。