Relationship between macular intercapillary area measured by optical coherence tomography angiography and central visual field sensitivity in normal tension glaucoma,British Journal of Ophthalmology

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Relationship between macular intercapillary area measured by optical coherence tomography angiography and central visual field sensitivity in normal tension glaucoma
British Journal of Ophthalmology ( IF 4.1 ) Pub Date : 2023-06-01 , DOI: 10.1136/bjophthalmol-2021-319923
Ruyue Shen ₁ , Yu Meng Wang ₁ , Carol Y Cheung _{1,

2} , Fang Yao Tang ₁ , Alexander Lam _{1,

3} , Clement C Tham _{2,

4,

5,

6} , Poemen PuiMan Chan _{2,

4,

5,

6}

Affiliation

Purpose To investigate the relationship of macular intercapillary area (ICA) with macular ganglion cell-inner plexiform layer (GCIPL) thickness and central visual field sensitivity (CVFS) in normal tension glaucoma (NTG). Methods Seventy-eight early NTG eyes, 33 moderate-to-severe NTG eyes and 75 normal control eyes were cross-sectional evaluated. All participants underwent swept-source optical coherence tomography angiography (OCT-A; DRI-OCT, Topcon, Tokyo, Japan). A customised MATLAB program was used to quantify macular OCT-A metrics at central 3×3 mm macular region including vascular density (VD), foveal avascular zone (FAZ) area, 10 largest ICA including FAZ area (ICA10\_IncFAZ) and excluding FAZ area (ICA10\_ExcFAZ). Generalised estimating equation regression models were performed to determine the relationships of OCT-A vascular metrics with GCIPL thickness in the macular region and CVFS. Results NTG eyes had lower global VD, larger ICA10\_IncFAZ, and larger ICA10\_ExcFAZ than normal controls (all p≤0.016). In the multivariable analyses, decreased VD (β=−0.304, p=0.006) and increased ICA (β=−0.231 for ICA10\_IncFAZ and β=−0.259 for ICA10\_ExcFAZ, all p≤0.042) were significantly associated with decreased GCIPL thickness in early NTG eyes but not in moderate-to-severe NTG eyes. ICA enlargement was associated with CVFS in early NTG eyes (β=−0.310, p=0.009), while VD was associated with CVFS in moderate-to-severe NTG eyes (β=−0.272, p=0.038). Conclusion ICA enlargement could be a potentially important disease marker of early NTG as reflected by its association with GCIPL thinning and decrease CVFS specifically for early NTG eyes. All data relevant to the study are included in the article or uploaded as online supplemental information. The patients’ data are keep in the Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong. We follow the University and Department protocol to ensure the safety of the patients’ data.

更新日期：2023-05-19

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