Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists—remains unknown. Cardiovascular diseases are the leading cause of mortality in India affecting 55 million people, and high blood pressure is one of the primary risk factors for cardiovascular diseases. We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Our analysis reveals a robust link between the gut microbiome diversity and composition and systolic blood pressure. Moreover, several genera previously associated with hypertension in non-Indian populations were also associated with systolic blood pressure in this cohort and these genera were predictors of elevated blood pressure in these populations. These findings confer opportunities to design personalized, preventative, and targeted interventions harnessing the gut microbiome to tackle the burden of cardiovascular diseases in India.

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与收缩压相关的人类肠道微生物

新兴研究揭示了肠道微生物组与几种人类疾病之间的密切联系。由于人类肠道微生物组反映了生活方式和环境的变化，疾病状况和肠道微生物组之间的关联是否在人群中是一致的——特别是在实施传统生存策略的社区中，其微生物组与工业家明显不同——仍然未知。在印度，心血管疾病是导致 5500 万人死亡的主要原因，而高血压是心血管疾病的主要危险因素之一。我们检查了肠道微生物组与血压之间的关联，以及与三个阿萨姆人群的生活方式、饮食习惯、疾病状况和临床血液标志物相关的 14 个其他变量。我们的分析揭示了肠道微生物群多样性和组成与收缩压之间的密切联系。此外，以前与非印度人群高血压相关的几个属也与该队列中的收缩压相关，这些属是这些人群血压升高的预测因子。这些发现为设计个性化、预防性和有针对性的干预措施提供了机会，利用肠道微生物组来解决印度心血管疾病的负担。以前与非印度人群高血压相关的几个属也与该队列中的收缩压相关，这些属是这些人群血压升高的预测因子。这些发现为设计个性化、预防性和有针对性的干预措施提供了机会，利用肠道微生物组来解决印度心血管疾病的负担。以前与非印度人群高血压相关的几个属也与该队列中的收缩压相关，这些属是这些人群血压升高的预测因子。这些发现为设计个性化、预防性和有针对性的干预措施提供了机会，利用肠道微生物组来解决印度心血管疾病的负担。