An innovative sandwich-structural Fe-based metal-organic framework magnetic material (Fe₃O₄@SW-MIL-101-NH₂) was fabricated using a facile solvothermal method. The characteristic properties of the material were investigated by field emission scanning electron microscopy, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction, vibrating sample magnetometry, and Brunauer-Emmett-Teller measurements. Fe₃O₄@SW-MIL-101-NH₂ is associated with advantages, such as robust magnetic properties, high specific surface area, and satisfactory storage stability, as well as good selective recognition ability for chlorogenic acid (CA) and its metabolites via chelation, hydrogen bonding, and π-interaction. The results of the static adsorption experiment indicated that Fe₃O₄@SW-MIL-101-NH₂ possessed a high adsorption capacity toward CA and its isomers, cryptochlorogenic acid (CCA) and neochlorogenic acid (NCA), and the adsorption behaviors were fitted using the Langmuir adsorption isotherm model. Then, a strategy using magnetic solid-phase extraction (MSPE) and ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF MS/MS) was developed and successfully employed for the selective pre-concentration and rapid identification of CA metabolites in rat plasma, urine, and feces samples. This work presents a prospective strategy for the synthesis of magnetic adsorbents and the high-efficiency pretreatment of CA metabolites.

使用简便的溶剂热法制造了一种创新的夹层结构铁基金属有机骨架磁性材料（Fe ₃ O ₄ @SW-MIL-101-NH _{2 ）。}通过场发射扫描电子显微镜、透射电子显微镜 (TEM)、能量色散 X 射线光谱、傅里叶变换红外光谱、X 射线粉末衍射、振动样品磁强计和 Brunauer-Emmett-柜员测量。Fe ₃ O ₄ @SW-MIL-101-NH ₂具有强大的磁性、高比表面积和令人满意的储存稳定性等优点，以及通过螯合、氢键和 π 相互作用对绿原酸 (CA) 及其代谢物的良好选择性识别能力。静态吸附实验结果表明，Fe ₃ O ₄ @SW-MIL-101-NH ₂对CA及其异构体隐绿原酸（CCA）和新绿原酸（NCA）具有较高的吸附能力，吸附行为采用朗缪尔吸附等温线模型拟合。然后，开发了一种使用磁性固相萃取 (MSPE) 和超高效液相色谱结合四极杆飞行时间串联质谱 (UPLC-Q-TOF MS/MS) 的策略，并成功用于选择性预大鼠血浆、尿液和粪便样品中 CA 代谢物的浓度和快速鉴定。这项工作为磁性吸附剂的合成和 CA 代谢物的高效预处理提供了一种前瞻性策略。