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The role of ROS in tumour development and progression
Nature Reviews Cancer ( IF 78.5 ) Pub Date : 2022-01-31 , DOI: 10.1038/s41568-021-00435-0
Eric C Cheung 1 , Karen H Vousden 1
Affiliation  

Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour from signalling to death, and deregulation of ROS production and ROS limitation pathways are common features of cancer cells. ROS also function to modulate the tumour environment, affecting the various stromal cells that provide metabolic support, a blood supply and immune responses to the tumour. Although it is clear that ROS play important roles during tumorigenesis, it has been difficult to reliably predict the effect of ROS modulating therapies. We now understand that the responses to ROS are highly complex and dependent on multiple factors, including the types, levels, localization and persistence of ROS, as well as the origin, environment and stage of the tumours themselves. This increasing understanding of the complexity of ROS in malignancies will be key to unlocking the potential of ROS-targeting therapies for cancer treatment.



中文翻译:

ROS在肿瘤发生发展中的作用

真核细胞已经开发出复杂的系统来调节活性氧 (ROS) 的产生和反应。不同的 ROS 控制从信号传导到死亡的细胞行为的不同方面,而 ROS 产生和 ROS 限制途径的失调是癌细胞的共同特征。ROS还具有调节肿瘤环境的作用,影响提供代谢支持、血液供应和对肿瘤免疫反应的各种基质细胞。尽管很明显 ROS 在肿瘤发生过程中起重要作用,但很难可靠地预测 ROS 调节疗法的效果。我们现在了解到,对 ROS 的反应非常复杂,取决于多种因素,包括 ROS 的类型、水平、定位和持久性,以及起源,肿瘤本身的环境和阶段。对恶性肿瘤中 ROS 复杂性的日益了解将是释放 ROS 靶向疗法在癌症治疗中的潜力的关键。

更新日期:2022-01-31
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