BACKGROUND According to the literature, pigmentary disorders have a significantly negative impact on a person's health-related quality of life. Moreover, among pigmentary disorders, incidence of melasma ranks high. The Melasma Area and Severity Index (MASI) is the scale that is generally used to evaluate a melasma-affected area and its severity. However, the relationship between the MASI and Melasma Quality of Life (MELASQoL) scores, as well as the impact of melasma on patients' quality of life, remain unclear. OBJECTIVES To explore the influence of melasma on patients' lives, analyze the relationship between the MASI and MELASQoL scores, and identify the factors that may be influencing the quality of life of patients with melasma. METHODS Two reviewers independently searched four databases (PubMed, Embase, the Cochrane Library, and Web of Science) for literature on quality of life of patients with melasma. In addition to an epidemiological study, a cross-sectional study, and validation studies, gray literature was also included. StataSE version 16 software was used for the meta-analysis. The score of each item on the MELASQoL scale was determined using a random-effects model. RESULTS Fourteen studies with a total of 1398 melasma patients were included in the systematic review, four of which were eligible for meta-analysis. The relationship between the MELASQoL and MASI scores was found to be mixed. Five studies concluded that the MASI and MELASQoL scores were statistically correlated, while seven studies found no statistical correlation between the two. It is obvious that melasma causes emotional distress and has a negative impact on patients' social lives. Patients were most bothered by the appearance of their skin condition. However, the MELASQoL score had no definite correlation with patient characteristics such as age, education levels, and history. CONCLUSION Melasma has a significant negative impact on patients' quality of life. Thus, evaluating the quality of life of patients with melasma should not be ignored. Additionally, utilization of the MELASQoL scale should be considered in the care plan. Further studies with larger sample sizes are needed to confirm the relationship between melasma and quality of life.

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使用 MELASQoL 量表评估黄褐斑患者的生活质量：系统评价和荟萃分析。

背景根据文献，色素障碍对人的健康相关生活质量具有显着的负面影响。此外，在色素性疾病中，黄褐斑的发病率居高不下。黄褐斑面积和严重程度指数 (MASI) 是通常用于评估受黄褐斑影响的区域及其严重程度的量表。然而，MASI 和黄褐斑生活质量 (MELASQoL) 评分之间的关​​系，以及黄褐斑对患者生活质量的影响，仍不清楚。目的探讨黄褐斑对患者生活的影响，分析MASI与MELASQoL评分之间的关​​系，找出可能影响黄褐斑患者生活质量的因素。方法 两名评审员独立检索了四个数据库（PubMed、Embase、Cochrane Library、和 Web of Science）获取有关黄褐斑患者生活质量的文献。除了流行病学研究、横断面研究和验证研究外，还包括灰色文献。StataSE 16 版软件用于荟萃分析。MELASQoL 量表上每个项目的分数是使用随机效应模型确定的。结果 共有 1398 名黄褐斑患者的 14 项研究被纳入系统评价，其中 4 项符合荟萃分析条件。发现 MELASQoL 和 MASI 分数之间的关系是混合的。五项研究得出结论，MASI 和 MELASQoL 评分具有统计学相关性，而七项研究发现两者之间没有统计学相关性。很明显，黄褐斑会引起情绪困扰，并对患者的社交生活产生负面影响。患者对其皮肤状况的出现最为困扰。然而，MELASQoL 评分与年龄、教育水平和病史等患者特征没有明确的相关性。结论黄褐斑对患者的生活质量有显着的负面影响。因此，评估黄褐斑患者的生活质量不容忽视。此外，在护理计划中应考虑使用 MELASQoL 量表。需要更大样本量的进一步研究来确认黄褐斑与生活质量之间的关系。因此，评估黄褐斑患者的生活质量不容忽视。此外，在护理计划中应考虑使用 MELASQoL 量表。需要更大样本量的进一步研究来确认黄褐斑与生活质量之间的关系。因此，评估黄褐斑患者的生活质量不容忽视。此外，在护理计划中应考虑使用 MELASQoL 量表。需要更大样本量的进一步研究来确认黄褐斑与生活质量之间的关系。