Introduction Immunosenescence leads to increased morbidity and mortality associated with viral infections and weaker vaccine responses. This has been well documented for seasonal influenza and the current pandemic with Sars-Cov2, which disproportionately impact older adults, particularly those in residential aged care facilities. Inadequate nutrient intake associated with impaired immunity, respiratory and muscle function are likely to augment the effects of immunosenescence. In this study, we test whether the effects of inadequate nutrition can be reversed by multi-nutrient supplementation, consequently enhancing vaccine responses, reducing the risk of viral infections, and improving respiratory and muscle function.

中文翻译：

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12 周多营养素补充剂对老年护理中老年人免疫和肌肉骨骼系统的影响（Pomerium 研究）：随机对照试验方案

简介免疫衰老导致与病毒感染和较弱的疫苗反应相关的发病率和死亡率增加。季节性流感和当前的 Sars-Cov2 大流行已经充分证明了这一点，这些流行病对老年人的影响尤其严重，尤其是居住在老年护理机构中的老年人。与免疫、呼吸和肌肉功能受损相关的营养摄入不足可能会增加免疫衰老的影响。在这项研究中，我们测试是否可以通过补充多种营养素来逆转营养不足的影响，从而增强疫苗反应，降低病毒感染的风险，并改善呼吸和肌肉功能。