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Hydroxylation decoration patterns of flavonoids in horticultural crops: chemistry, bioactivity and biosynthesis.
Horticulture Research ( IF 8.7 ) Pub Date : 2022-01-20 , DOI: 10.1093/hr/uhab068 Yilong Liu 1, 2 , Jiafei Qian 1 , Jiajia Li 1 , Mengyun Xing 1 , Donald Grierson 1, 3 , Chongde Sun 1, 2 , Changjie Xu 1 , Xian Li 1, 2 , Kunsong Chen 1, 2
Horticulture Research ( IF 8.7 ) Pub Date : 2022-01-20 , DOI: 10.1093/hr/uhab068 Yilong Liu 1, 2 , Jiafei Qian 1 , Jiajia Li 1 , Mengyun Xing 1 , Donald Grierson 1, 3 , Chongde Sun 1, 2 , Changjie Xu 1 , Xian Li 1, 2 , Kunsong Chen 1, 2
Affiliation
Flavonoids are the most widespread polyphenolic compounds and are important dietary constituents present in horticultural crops such as fruits, vegetables, and tea. Natural flavonoids are responsible for important quality traits, such as food colors and beneficial dietary antioxidants and numerous investigations have shown that intake of flavonoids can reduce the incidence of various non-communicable diseases (NCDs). Analysis of the thousands of flavonoids reported so far has shown that different hydroxylation modifications affect their chemical properties and nutritional values. These diverse flavonoids can be classified based on different hydroxylation patterns in the B, C, A rings and multiple structure-activity analyses have shown that hydroxylation decoration at specific positions markedly enhances their bioactivities. This review focuses on current knowledge concerning hydroxylation of flavonoids catalyzed by several different types of hydroxylase enzymes. Flavonoid 3'-hydroxylase (F3'H) and flavonoid 3'5'-hydroxylase (F3'5'H) are important enzymes for the hydroxylation of the B ring of flavonoids. Flavanone 3-hydroxylase (F3H) is key for the hydroxylation of the C ring, while flavone 6-hydroxylase (F6H) and flavone 8-hydroxylase (F8H) are key enzymes for hydroxylation of the A ring. These key hydroxylases in the flavonoid biosynthesis pathway are promising targets for the future bioengineering of plants and mass production of flavonoids with designated hydroxylation patterns of high nutritional importance. In addition, hydroxylation in key places on the ring may help render flavonoids ready for degradation, the catabolic turnover of which may open the door for new lines of inquiry.
中文翻译:
园艺作物中类黄酮的羟基化修饰模式:化学、生物活性和生物合成。
类黄酮是分布最广的多酚化合物,是水果、蔬菜和茶叶等园艺作物中重要的膳食成分。天然类黄酮对重要的品质特性负责,例如食用色素和有益的膳食抗氧化剂,大量研究表明,摄入类黄酮可以降低各种非传染性疾病 (NCD) 的发病率。对迄今为止报道的数千种类黄酮的分析表明,不同的羟基化修饰会影响它们的化学性质和营养价值。这些不同的类黄酮可以根据 B、C、A 环中不同的羟基化模式进行分类,并且多重结构活性分析表明,特定位置的羟基化修饰显着增强了它们的生物活性。本综述侧重于当前有关由几种不同类型的羟化酶催化的类黄酮羟基化的知识。类黄酮3'-羟化酶(F3'H)和类黄酮3'5'-羟化酶(F3'5'H)是类黄酮B环羟基化的重要酶。黄烷酮 3-羟化酶 (F3H) 是 C 环羟基化的关键酶,而黄酮 6-羟化酶 (F6H) 和黄酮 8-羟化酶 (F8H) 是 A 环羟基化的关键酶。类黄酮生物合成途径中的这些关键羟化酶是未来植物生物工程和大规模生产具有高营养重要性的指定羟基化模式的类黄酮的有前途的目标。此外,环上关键位置的羟基化可能有助于使类黄酮做好降解准备,
更新日期:2022-01-20
中文翻译:
园艺作物中类黄酮的羟基化修饰模式:化学、生物活性和生物合成。
类黄酮是分布最广的多酚化合物,是水果、蔬菜和茶叶等园艺作物中重要的膳食成分。天然类黄酮对重要的品质特性负责,例如食用色素和有益的膳食抗氧化剂,大量研究表明,摄入类黄酮可以降低各种非传染性疾病 (NCD) 的发病率。对迄今为止报道的数千种类黄酮的分析表明,不同的羟基化修饰会影响它们的化学性质和营养价值。这些不同的类黄酮可以根据 B、C、A 环中不同的羟基化模式进行分类,并且多重结构活性分析表明,特定位置的羟基化修饰显着增强了它们的生物活性。本综述侧重于当前有关由几种不同类型的羟化酶催化的类黄酮羟基化的知识。类黄酮3'-羟化酶(F3'H)和类黄酮3'5'-羟化酶(F3'5'H)是类黄酮B环羟基化的重要酶。黄烷酮 3-羟化酶 (F3H) 是 C 环羟基化的关键酶,而黄酮 6-羟化酶 (F6H) 和黄酮 8-羟化酶 (F8H) 是 A 环羟基化的关键酶。类黄酮生物合成途径中的这些关键羟化酶是未来植物生物工程和大规模生产具有高营养重要性的指定羟基化模式的类黄酮的有前途的目标。此外,环上关键位置的羟基化可能有助于使类黄酮做好降解准备,