OBJECTIVE Previous studies have investigated the incidence of type 2 diabetes in individuals with psychiatric disorders, but most studies have focused on a specific psychiatric disorder or a selected sample. More population-based studies are needed to determine these associations in representative samples. We therefore aimed to determine these associations in a nationwide, register-based dynamic cohort study. RESEARCH DESIGN AND METHODS We analyzed data from 5,005,612 adults living in Denmark between 1995 and 2018, without prior diabetes. We investigated 10 different categories of psychiatric disorders and a composite group with any psychiatric disorder. Individuals with a psychiatric disorder were compared with individuals without using multivariable-adjusted Poisson regression to estimate incidence rate ratios (IRR) of type 2 diabetes. We modeled age-specific incidence rates (IR) for individuals with and without the specific psychiatric disorder. All models were stratified by sex. RESULTS In total, 334,739 individuals developed type 2 diabetes during follow-up. For all investigated categories of psychiatric disorders, we found increased IR of type 2 diabetes for individuals with versus those without a psychiatric disorder (IRR: men, 1.47 [95% CI 1.45–1.50]; women, 1.65 [95% CI 1.62–1.68]). When we examined age-specific IR, the largest differences were found in the younger population (<50 years). CONCLUSIONS We found that the IR of type 2 diabetes was higher in individuals with a psychiatric disorder compared with individuals without a psychiatric disorder and particularly high in the younger people with a psychiatric disorder. New studies into the prevention and early detection of type 2 diabetes in these groups are warranted.

中文翻译：

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患有精神疾病的个体患 2 型糖尿病的风险：一项基于全国登记的队列研究

目的 以前的研究调查了精神疾病患者 2 型糖尿病的发病率，但大多数研究都集中在特定的精神疾病或选定的样本上。需要更多基于人群的研究来确定代表性样本中的这些关联。因此，我们的目标是在一项全国性的、基于登记的动态队列研究中确定这些关联。研究设计和方法 我们分析了 1995 年至 2018 年间居住在丹麦的 5,005,612 名成年人的数据，这些成年人之前没有糖尿病。我们调查了 10 种不同类别的精神疾病和任何精神疾病的复合组。将患有精神疾病的个体与未使用多变量调整泊松回归估计 2 型糖尿病的发病率比 (IRR) 的个体进行比较。我们模拟了患有和不患有特定精神疾病的个体的年龄特异性发病率 (IR)。所有模型均按性别分层。结果 总共有 334,739 人在随访期间发展为 2 型糖尿病。对于所有研究的精神疾病类别，我们发现患有精神疾病的个体与没有精神疾病的个体的 2 型糖尿病的 IR 增加（IRR：男性，1.47 [95% CI 1.45–1.50]；女性，1.65 [95% CI 1.62–1.68] ]）。当我们检查特定年龄的 IR 时，发现最大的差异出现在较年轻的人群中（<50 岁）。结论 我们发现，与没有精神疾病的个体相比，患有精神疾病的个体的 2 型糖尿病的 IR 更高，尤其是在患有精神疾病的年轻人中更高。