Abstract

Background

Regardless of age at presentation, many soft tissue neoplasms have overlapping histopathologic and immunophenotypic features to serve as a diagnostic challenge.

Case report

We reported a case of a spindle cell neoplasm in an infant, which was initially considered a vascular anomaly clinically and an eventual biopsy revealed marked inflammation with a spindle cell component that was resolved as an infantile fibrosarcoma with an ETV6 break-apart.

Conclusion

The context of this case lead to a further consideration of various other spindle cell neoplasms arising predominantly in the soft tissues during the infancy period as defined by the first two years of age. Though sharing similar morphologic features, these tumors can be categorized into several molecular genetic groups, which have provided both diagnostic and pathogenetic insights as well as treatment options in some cases.

中文翻译：

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婴儿纤维肉瘤和其他婴儿梭形细胞肿瘤。形态重叠但分子独特的实体的回顾

摘要

背景

无论就诊时的年龄如何，许多软组织肿瘤具有重叠的组织病理学和免疫表型特征，以作为诊断挑战。

案例报告

我们报告了一例婴儿梭形细胞肿瘤，最初在临床上被认为是血管异常，最终活检显示有梭形细胞成分的明显炎症，被解决为具有ETV6分裂的婴儿纤维肉瘤。

结论

该病例的背景导致进一步考虑各种其他梭形细胞肿瘤，主要发生在婴儿期（定义为头两岁）的软组织中。尽管具有相似的形态学特征，但这些肿瘤可以分为几个分子遗传组，这些组在某些情况下提供了诊断和发病机制的见解以及治疗选择。