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Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication
GeroScience ( IF 5.6 ) Pub Date : 2022-01-17 , DOI: 10.1007/s11357-022-00516-4
Cheng-Ya Huang , Liang-Chi Chen , Ruey-Meei Wu , Ing-Shiou Hwang

Appropriate attentional resource allocation could minimize exaggerated dual-task interference due to basal ganglia dysfunction in Parkinson’s disease (PD). Here, we assessed the electroencephalography (EEG) functional connectivity to investigate how task prioritization affected posture-motor dual-tasks in PD. Sixteen early-stage PD patients and 16 healthy controls maintained balance in narrow stance alone (single-posture task) or while separating two interlocking rings (postural dual-task). The participants applied a posture-focus or supraposture-focus strategy in the postural dual-task. Postural sway dynamics, ring-touching time, and scalp EEG were analyzed. Both groups exhibited smaller postural sway size, postural determinism, and ring-touching time with the supraposture-focus versus posture-focus strategy. PD patients exhibited higher mean inter-regional connectivity strength than control subjects in both single and dual-task postural conditions. To cope with dual-task interference, PD patients increased inter-regional connectivity (especially with the posture-focus strategy), while control subjects reduced inter-regional connectivity. The difference in mean connectivity strength between the dual-task condition with supraposture-focus and single-posture condition was negatively correlated to the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III total scores and hand-related sub-scores. Our findings suggest differential task prioritization effects on dual-task performance and cortical reorganization between early-stage PD and healthy individuals. Early-stage PD patients are advocated to use a supraposture-focus strategy during a postural dual-task. In addition, with a supraposture-focus strategy, PD patients with mild motor severity could increase compensatory inter-regional connectivity to cope with dual-task interference.



中文翻译:

任务优先级对早期帕金森病姿势运动任务的影响:EEG 连通性和临床意义

适当的注意力资源分配可以最大限度地减少由于帕金森氏病 (PD) 基底神经节功能障碍导致的双重任务干扰。在这里,我们评估了脑电图 (EEG) 功能连接,以研究任务优先级如何影响 PD 中的姿势运动双重任务。16 名早期 PD 患者和 16 名健康对照者单独在狭窄的姿势(单一姿势任务)或分离两个互锁环(姿势双重任务)时保持平衡。参与者在姿势双重任务中应用姿势聚焦或超姿势聚焦策略。分析了姿势摇摆动力学、环接触时间和头皮脑电图。两组都表现出较小的姿势摇摆大小、姿势决定论和环接触时间与姿势聚焦策略相比姿势聚焦策略。在单任务和双任务姿势条件下,PD 患者的平均区域间连接强度均高于对照组。为了应对双重任务干扰,PD 患者增加了区域间连接(尤其是使用姿势聚焦策略),而对照组则减少了区域间连接。具有超姿势聚焦的双重任务条件和单一姿势条件之间的平均连接强度差异与运动障碍协会统一帕金森病评定量表(MDS-UPDRS)第三部分总分和手部相关子分数呈负相关. 我们的研究结果表明,不同的任务优先级对早期 PD 和健康个体的双重任务表现和皮质重组有不同的影响。提倡早期 PD 患者在姿势双重任务期间使用超姿势聚焦策略。此外,通过超姿势聚焦策略,具有轻度运动严重程度的 PD 患者可以增加补偿性区域间连接以应对双重任务干扰。

更新日期:2022-01-18
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