Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons,Clinical Infectious Diseases

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2022-01-13 , DOI: 10.1093/cid/ciac029
Jamin Liu _{1,

2} , Matthew T Laurie ₂ , Luis Rubio ₃ , Sara E Vazquez _{2,

4} , Sara Sunshine ₂ , Anthea M Mitchell _{2,

5} , Matthias Hapte-Selassie _{2,

5} , Sabrina A Mann _{2,

5} , Genay Pilarowski _{6,

7} , Douglas Black ₃ , Carina Marquez ₃ , Susana Rojas ₇ , Michail S Lionakis ₈ , Maya Petersen ₉ , Jeffrey D Whitman ₁₀ , Vivek Jain ₃ , Mark Anderson ₄ , Diane Havlir ₃ , Joseph DeRisi _{2,

5}

Affiliation

University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, California, USA.
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, California, USA.
Department of Medicine, Diabetes Center, University of California, San Francisco, San Francisco, California, USA.
Chan Zuckerberg Biohub, San Francisco, California, USA.
The Public Health Company, Oakland, California, USA.
Unidos en Salud, San Francisco, California, USA.
Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Division of Biostatistics, University of California, Berkeley, Berkeley, California, USA.
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.

While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination “breakthrough” COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.

中文翻译：

严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 在接种疫苗的家庭中的传播动态和免疫反应

虽然 SARS-CoV-2 疫苗可以有效预防严重疾病，但接种后“突破性”COVID-19 感染和接种者之间的传播仍然令人担忧。我们对家庭中接种疫苗的个体之间的传播和免疫进行了深入的描述，揭示了复杂的动态和未被重视的合并症，包括推定指标病例中对 1 型干扰素的自身免疫。

更新日期：2022-01-13

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