Urinary tract infection (UTI) is the most common and life-threatening bacterial infection among neonates. This study aimed to determine the prevalence, aetiology, and susceptible antimicrobial agents among neonates with UTI. This was a cross-sectional analytical hospital-based study that included 152 neonates with clinical sepsis who were admitted at Dodoma regional referral hospital from January to June 2020. Bacterial growth of 1 × 103 colony forming units/mL of a single uropathogen was used to define the presence of UTI. Statistical analysis was performed using SPSS version 23.0 and multivariate analysis was used to determine the predicting factors of UTI. P <0.05 was regarded statistically significant. The prevalence of UTI was 18.4% (28/152). Klebsiella pneumoniae 64.3% (18/28) and Enterobacter spp. 35.7% (10/28) were the bacterial agents isolated. The bacterial isolates were 90%, and 60% sensitive to ciprofloxacin and amikacin, respectively. Low Apgar score (AOR = 12.76, 95% CI = 4.17–39.06, p<0.001), prolonged labour (AOR = 5.36, 95% CI = 1.28–22.52, p = 0.022), positive urine nitrite test (AOR = 26.67, 95% CI = 7.75–91.70, p<0.001), and positive leucocyte esterase test (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) were potential predictors of UTI. The prevalence of UTI confirmed by urine culture among neonates that were included in the present study indicates that this problem is common in the population where the study was conducted. Klebsiella pneumoniae and Enterobacter spp. were the uropathogens which were isolated. Ciprofloxacin, nitrofurantoin, and amikacin were sensitive to the isolated uropathogens.

中文翻译：

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临床败血症新生儿的患病率、病因、抗菌药物敏感性试验和尿路感染预测因素：一项横断面研究

尿路感染 (UTI) 是新生儿中最常见和威胁生命的细菌感染。本研究旨在确定 UTI 新生儿的患病率、病因和敏感抗菌药物。这是一项基于医院的横断面分析研究，包括 2020 年 1 月至 2020 年 6 月在 Dodoma 地区转诊医院收治的 152 名临床败血症新生儿。细菌生长为 1 × 103 菌落形成单位/mL 的单一尿路病原体用于检测定义 UTI 的存在。使用SPSS 23.0版进行统计分析，并使用多变量分析确定UTI的预测因素。P <0.05被认为具有统计学意义。UTI 的患病率为 18.4% (28/152)。肺炎克雷伯菌 64.3% (18/28) 和肠杆菌属。35. 7% (10/28) 是分离的细菌剂。细菌分离物对环丙沙星和阿米卡星的敏感性分别为 90% 和 60%。Apgar 评分低 (AOR = 12.76, 95% CI = 4.17–39.06, p<0.001)，产程延长 (AOR = 5.36, 95% CI = 1.28–22.52, p = 0.022)，尿亚硝酸盐检测阳性 (AOR = 26.67, 95% CI = 7.75–91.70, p<0.001) 和阳性白细胞酯酶试验 (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) 是 UTI 的潜在预测因子。本研究中纳入的新生儿尿培养证实了尿路感染的患病率，这表明该问题在进行研究的人群中很常见。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。细菌分离物对环丙沙星和阿米卡星的敏感性分别为 90% 和 60%。Apgar 评分低 (AOR = 12.76, 95% CI = 4.17–39.06, p<0.001)，产程延长 (AOR = 5.36, 95% CI = 1.28–22.52, p = 0.022)，尿亚硝酸盐检测阳性 (AOR = 26.67, 95% CI = 7.75–91.70, p<0.001) 和阳性白细胞酯酶试验 (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) 是 UTI 的潜在预测因子。本研究中纳入的新生儿尿培养证实了尿路感染的患病率，这表明该问题在进行研究的人群中很常见。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。细菌分离物对环丙沙星和阿米卡星的敏感性分别为 90% 和 60%。Apgar 评分低 (AOR = 12.76, 95% CI = 4.17–39.06, p<0.001)，产程延长 (AOR = 5.36, 95% CI = 1.28–22.52, p = 0.022)，尿亚硝酸盐检测阳性 (AOR = 26.67, 95% CI = 7.75–91.70, p<0.001) 和阳性白细胞酯酶试验 (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) 是 UTI 的潜在预测因子。本研究中纳入的新生儿尿培养证实了尿路感染的患病率，这表明该问题在进行研究的人群中很常见。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。Apgar 评分低 (AOR = 12.76, 95% CI = 4.17–39.06, p<0.001)，产程延长 (AOR = 5.36, 95% CI = 1.28–22.52, p = 0.022)，尿亚硝酸盐检测阳性 (AOR = 26.67, 95% CI = 7.75–91.70, p<0.001) 和阳性白细胞酯酶试验 (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) 是 UTI 的潜在预测因子。本研究中纳入的新生儿尿培养证实了尿路感染的患病率，这表明该问题在进行研究的人群中很常见。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。Apgar 评分低 (AOR = 12.76, 95% CI = 4.17–39.06, p<0.001)，产程延长 (AOR = 5.36, 95% CI = 1.28–22.52, p = 0.022)，尿亚硝酸盐检测阳性 (AOR = 26.67, 95% CI = 7.75–91.70, p<0.001) 和阳性白细胞酯酶试验 (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) 是 UTI 的潜在预测因子。本研究中纳入的新生儿尿培养证实了尿路感染的患病率，这表明该问题在进行研究的人群中很常见。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。95% CI = 7.75–91.70, p<0.001) 和阳性白细胞酯酶试验 (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) 是 UTI 的潜在预测因子。本研究中纳入的新生儿尿培养证实了尿路感染的患病率，这表明该问题在进行研究的人群中很常见。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。95% CI = 7.75–91.70, p<0.001) 和阳性白细胞酯酶试验 (AOR = 6.64, 95% CI = 1.47–29.97, p = 0.014) 是 UTI 的潜在预测因子。本研究中纳入的新生儿尿培养证实了尿路感染的患病率，这表明该问题在进行研究的人群中很常见。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。肺炎克雷伯菌和肠杆菌属。是被分离的尿路病原体。环丙沙星、呋喃妥因和阿米卡星对分离的尿路病原体敏感。