HCC is a highly aggressive and heterogeneous cancer type with limited treatment options. Identifying drivers of tumor heterogeneity may lead to better therapeutic options and favorable patient outcomes. We investigated whether apoptotic cell death and its spatial architecture is linked to tumor molecular heterogeneity using single-cell in situ hybridization analysis.

中文翻译：

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单细胞生物学揭示了凋亡细胞死亡及其空间组织作为 HCC 肿瘤多样性的潜在调节剂

HCC 是一种高度侵袭性和异质性的癌症类型，治疗选择有限。确定肿瘤异质性的驱动因素可能会导致更好的治疗选择和有利的患者结果。我们使用单细胞原位杂交分析研究了凋亡细胞死亡及其空间结构是否与肿瘤分子异质性有关。