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Impact of biannual mass azithromycin treatment on enteropathogen carriage in children younger than 5 years in Niger
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2022-01-08 , DOI: 10.1093/cid/ciab1046
James A Platts-Mills 1 , Elias G Ayoub 2 , Jixian Zhang 1 , Elizabeth T Rogawski McQuade 3 , Ahmed M Arzika 4 , Ramatou Maliki 4 , Amza Abdou 5 , Jeremy D Keenan 6 , Thomas M Lietman 6 , Jie Liu 1 , Eric R Houpt 1
Affiliation  

We analyzed samples obtained at baseline and 24 months in a mass azithromycin administration trial in Niger using qPCR. In villages randomized to azithromycin, Shigella was the only pathogen reduced at 24 months (prevalence ratio: 0.36, 95% CI 0.17, 0.79 and -0.42 difference in log quantity, 95% CI -0.75, -0.10).

中文翻译:

尼日尔半年一次的大量阿奇霉素治疗对 5 岁以下儿童肠道病原体携带的影响

我们使用 qPCR 分析了在尼日尔进行的大规模阿奇霉素给药试验中在基线和 24 个月时获得的样本。在随机接受阿奇霉素治疗的村庄中,志贺氏菌是 24 个月时唯一减少的病原体(患病率:0.36,95% CI 0.17、0.79 和 -0.42 对数数量差异,95% CI -0.75,-0.10)。
更新日期:2022-01-08
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