RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70–83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.

中文翻译：

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指导 RNA 杂技：一对二洗牌

RNA 修饰对于 RNA 的正常功能至关重要。假尿苷的位点通常由双发夹导向 RNA 指定，其中一个或两个发夹识别目标尿苷。在本期《基因与发展》中，Jády 及其同事（第 70-83 页）确定了一种新机制，通过该机制，单个引导 RNA 发夹可以指定两个彼此相邻或相隔 1 nt 的尿苷；即一对二或指导 RNA 杂技。