There is some controversy regarding the interactions between creatine (CRE) and caffeine (CAF) supplements. The aim of this systematic review was to study whether such ergogenic interaction occurs and to analyze the protocol to optimize their synchronous use. The PubMed, Web of Science, MEDLINE, CINAHL, and SPORTDiscus databases were searched until November 2021 following the PRISMA guidelines. Ten studies were included. Three studies observed that CRE loading before an acute dose of CAF before exercise did not interfere in the beneficial effect of CAF, whereas one study reported that only an acute supplementation (SUP) of CAF was beneficial but not the acute SUP of both. When chronic SUP with CRE + CAF was used, two studies reported that CAF interfered in the beneficial effect of CRE, whereas three studies did not report interaction between concurrent SUP, and one study reported synergy. Possible mechanisms of interaction are opposite effects on relaxation time and gastrointestinal distress derived from concurrent SUP. CRE loading does not seem to interfere in the acute effect of CAF. However, chronic SUP of CAF during CRE loading could interfere in the beneficial effect of CRE.

关于肌酸 (CRE) 和咖啡因 (CAF) 补充剂之间的相互作用存在一些争议。本系统评价的目的是研究是否会发生这种强效相互作用，并分析协议以优化它们的同步使用。根据 PRISMA 指南，检索了 PubMed、Web of Science、MEDLINE、CINAHL 和 SPORTDiscus 数据库，直到 2021 年 11 月。包括十项研究。三项研究观察到，运动前急性剂量 CAF 之前的 CRE 负荷不会干扰 CAF 的有益效果，而一项研究报告说，只有 CAF 的急性补充 (SUP) 是有益的，但两者的急性 SUP 都没有。当使用 CRE + CAF 的慢性 SUP 时，两项研究报告说 CAF 干扰了 CRE 的有益作用，而三项研究没有报告并发 SUP 之间的相互作用，一项研究报告了协同作用。可能的相互作用机制是对来自并发 SUP 的松弛时间和胃肠道不适的相反影响。CRE 负荷似乎不会干扰 CAF 的急性作用。然而，CRE 负荷期间 CAF 的慢性 SUP 可能会干扰 CRE 的有益作用。