Humans produce and remove 1011 platelets daily to maintain a steady-state platelet count. The tight regulation of platelet production and removal from the blood circulation prevents anomalies in both processes from resulting in reduced or increased platelet count, often associated with the risk of bleeding or overt thrombus formation, respectively. This review focuses on the role of glycans, also known as carbohydrates or oligosaccharides, including N- and O-glycans, proteoglycans, and glycosaminoglycans, in human and mouse platelet and megakaryocyte physiology. Based on recent clinical observations and mouse models, we focused on the pathologic aspects of glycan biosynthesis and degradation and their effects on platelet numbers and megakaryocyte function.

中文翻译：

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聚糖对血小板和巨核细胞生物学的临床影响。

人类每天产生和去除 1011 个血小板以维持稳定的血小板计数。血小板生成和从血液循环中清除的严格调节可防止这两个过程中的异常导致血小板计数减少或增加，这通常分别与出血或明显血栓形成的风险相关。本综述侧重于聚糖（也称为碳水化合物或寡糖）在人和小鼠血小板和巨核细胞生理学中的作用，包括 N- 和 O- 聚糖、蛋白聚糖和糖胺聚糖。基于最近的临床观察和小鼠模型，我们专注于聚糖生物合成和降解的病理方面及其对血小板数量和巨核细胞功能的影响。