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Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients
Reaction Chemistry & Engineering ( IF 3.9 ) Pub Date : 2021-12-30 , DOI: 10.1039/d1re00483b
Cloudius R. Sagandira 1 , Sinazo Nqeketo 1 , Kanyisile Mhlana 1 , Thembela Sonti 1 , Sibongiseni Gaqa 1 , Paul Watts 1
Affiliation  

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical ingredients (APIs), inline flow downstream processing, in-process monitoring by process analytical technology (PAT) in flow, flow automation and artificial intelligence (AI) and robotics. We envisage that the integration of all these techniques can ensure an ‘ideal’ smart and efficient 21st century API chemical process that dramatically improves efficiency, agility, quality and flexibility in the manufacturing of pharmaceuticals.

中文翻译:

迈向第四次工业革命 高效且可持续的活性药物成分连续流制造

连续流动化学在实验室和制药行业都开辟了新的范例。这篇综述详细介绍了最近报道的关于活性药物成分 (API) 的连续多步伸缩合成、在线流程下游加工、流程分析技术 (PAT) 的流程监控、流程自动化和人工智能 (AI) 以及机器人技术的文献。我们设想,所有这些技术的整合可以确保“理想的”智能和高效的 21 世纪 API 化学工艺,从而显着提高药品制造的效率、敏捷性、质量和灵活性。
更新日期:2022-01-12
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