Summary: Aberrant DNA cytosine methylation is a critical contributor to compromised tissue regeneration and malignant transformation, particularly during aging. In this issue of Cancer Discovery, Huang and colleagues define a new class of disease-associated DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) variants with decreased de novo DNA methylation activity due increased proteasomal degradation that are able to drive clonal expansion of hematopoietic stem cells. See related article by Huang et al., p. 220.

中文翻译：

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降级或不降级 DNMT3A

摘要：异常的 DNA 胞嘧啶甲基化是组织再生受损和恶性转化的关键因素，尤其是在衰老过程中。在本期《Cancer Discovery》中，Huang 及其同事定义了一类新的疾病相关 DNA (胞嘧啶-5-)-甲基转移酶 3 α (DNMT3A) 变体，其由于蛋白酶体降解增加而导致从头 DNA 甲基化活性降低，能够驱动克隆造血干细胞的扩增。参见 Huang 等人的相关文章，第 17 页。220.