Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD,Hepatology

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Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD
Hepatology ( IF 13.5 ) Pub Date : 2022-01-09 , DOI: 10.1002/hep.32324
Mary P Moore _{1,

2} , Rory P Cunningham _{1,

2} , Grace M Meers _{1,

2} , Sarah A Johnson _{1,

3} , Andrew A Wheeler ₄ , Rama R Ganga ₄ , Nicole M Spencer ₄ , James B Pitt ₄ , Alberto Diaz-Arias ₅ , Ahmed I A Swi ₃ , Ghassan M Hammoud ₃ , Jamal A Ibdah _{1,

2,

3} , Elizabeth J Parks _{2,

3} , R Scott Rector _{1,

2,

3}

Affiliation

NAFLD and its more-advanced form, steatohepatitis (NASH), is associated with obesity and is an independent risk factor for cardiovascular, liver-related, and all-cause mortality. Available human data examining hepatic mitochondrial fatty acid oxidation (FAO) and hepatic mitochondrial turnover in NAFLD and NASH are scant.

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