Chronic HBV infection (CHI) is associated with a diverse natural history that includes immune-tolerant (IT), HBeAg-positive chronic hepatitis B (CHB) (EP-CHB), inactive carrier, and HBeAg-negative CHB (EN-CHB) phases. A hallmark of CHI is impairment of HBV-specific T-cell response. Recently, myeloid-derived suppressor cells (MDSCs) have emerged as key regulator of T cells, and their properties are sculpted by their microenvironment. Here, we investigated the distinctive features of MDSCs during CHI, identified factors responsible for their functional discrepancies, and studied their impact on HBV-specific T-cell response and homing. Influence of antiviral therapy on MDSC profile and T-cell response was also assessed.

中文翻译：

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MDSC 在慢性 HBV 感染不同阶段的不同方面：对 HBV 特异性 T 细胞反应和归巢的影响

慢性 HBV 感染 (CHI) 与多种自然病程相关，包括免疫耐受 (IT)、HBeAg 阳性慢性乙型肝炎 (CHB) (EP-CHB)、非活动携带者和 HBeAg 阴性 CHB (EN-CHB)阶段。CHI 的一个标志是 HBV 特异性 T 细胞反应受损。最近，髓源性抑制细胞 (MDSCs) 已成为 T 细胞的关键调节因子，它们的特性是由它们的微环境决定的。在这里，我们调查了 CHI 期间 MDSC 的独特特征，确定了导致其功能差异的因素，并研究了它们对 HBV 特异性 T 细胞反应和归巢的影响。还评估了抗病毒治疗对 MDSC 谱和 T 细胞反应的影响。