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TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase–mediated hepatocyte transdifferentiation
Hepatology ( IF 13.5 ) Pub Date : 2022-01-07 , DOI: 10.1002/hep.32317 Yuto Shiode 1 , Takahiro Kodama 1 , Satoshi Shigeno 1 , Kazuhiro Murai 1 , Satoshi Tanaka 2 , Justin Y Newberg 3 , Jumpei Kondo 4 , Shogo Kobayashi 5 , Ryoko Yamada 1 , Hayato Hikita 1 , Ryotaro Sakamori 1 , Hiroshi Suemizu 6 , Tomohide Tatsumi 1 , Hidetoshi Eguchi 5 , Nancy A Jenkins 3, 7 , Neal G Copeland 3, 7 , Tetsuo Takehara 1
Hepatology ( IF 13.5 ) Pub Date : 2022-01-07 , DOI: 10.1002/hep.32317 Yuto Shiode 1 , Takahiro Kodama 1 , Satoshi Shigeno 1 , Kazuhiro Murai 1 , Satoshi Tanaka 2 , Justin Y Newberg 3 , Jumpei Kondo 4 , Shogo Kobayashi 5 , Ryoko Yamada 1 , Hayato Hikita 1 , Ryotaro Sakamori 1 , Hiroshi Suemizu 6 , Tomohide Tatsumi 1 , Hidetoshi Eguchi 5 , Nancy A Jenkins 3, 7 , Neal G Copeland 3, 7 , Tetsuo Takehara 1
Affiliation
Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
中文翻译：
TNF 受体相关因子 3 失活通过 NF-κB 诱导激酶介导的肝细胞转分化促进肝内胆管癌的发展
肝内胆管癌 (ICC) 是一种致命但知之甚少的疾病，其治疗选择非常有限。本研究的目的是确定 ICC 的分子驱动因素并寻找治疗靶点。
更新日期：2022-02-10
中文翻译：
TNF 受体相关因子 3 失活通过 NF-κB 诱导激酶介导的肝细胞转分化促进肝内胆管癌的发展
肝内胆管癌 (ICC) 是一种致命但知之甚少的疾病，其治疗选择非常有限。本研究的目的是确定 ICC 的分子驱动因素并寻找治疗靶点。
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