Brain Biopsy for Neurological Diseases of Unknown Etiology in Critically Ill Patients: Feasibility, Safety, and Diagnostic Yield.,Critical Care Medicine

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Brain Biopsy for Neurological Diseases of Unknown Etiology in Critically Ill Patients: Feasibility, Safety, and Diagnostic Yield.
Critical Care Medicine ( IF 8.8 ) Pub Date : 2022-01-10 , DOI: 10.1097/ccm.0000000000005439
Bertrand Mathon _{1,

2} , Malory Favreau ₃ , Vincent Degos ₃ , Aymeric Amelot ₁ , Alexandre Le Joncour ₄ , Nicolas Weiss _{5,

6} , Benjamin Rohaut _{2,

5} , Loïc Le Guennec ₅ , Anne-Laure Boch ₁ , Alexandre Carpentier ₁ , Franck Bielle _{2,

7} , Karima Mokhtari ₇ , Ahmed Idbaih _{2,

8} , Mehdi Touat _{2,

8} , Alain Combes ₉ , Alexandre Demoule _{10,

11} , Eimad Shotar ₁₂ , Vincent Navarro _{2,

13} , Mathieu Raux ₁₄ , Sophie Demeret ₅ , Marc Pineton De Chambrun _{9,

15,

16} ,

Affiliation

Department of Neurosurgery, AP-HP, Sorbonne University, La Pitié-Salpêtrière Hospital, Paris, France.
Paris Brain Institute, ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, UMRS 1127, Paris, France.
Department of Neurosurgical Anesthesiology and Critical Care, AP-HP, Sorbonne University, La Pitié Salpêtrière Hospital, Paris, France.
Department of Internal Medicine and Clinical Immunology, AP-HP, Sorbonne University, La Pitié Salpêtrière Hospital, Paris, France.
Department of Neurology, Neuro-ICU, AP-HP, Sorbonne University, La Pitié-Salpêtrière Hospital, Paris, France.
Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR S 938, Centre de Recherche Saint-Antoine, Sorbonne University, Paris, France.
Department of Neuropathology, AP-HP, Sorbonne University, La Pitié-Salpêtrière Hospital, Paris, France.
Department of Neurology, Sorbonne University, DMU Neurosciences, AP-HP, La Pitié-Salpêtrière Hospital, Paris, France.
Intensive Care Medicine Department, AP-HP, Sorbonne University, La Pitié-Salpêtrière Hospital, Paris, France.
Intensive Care Medicine Department (R3S Department), AP-HP, Sorbonne University, La Pitié-Salpêtrière Hospital, Paris, France.
INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Department of Neuroradiology, AP-HP, Sorbonne University, La Pitié-Salpêtrière Hospital, Paris, France.
Department of Neurology, Epileptology Unit, AP-HP, Sorbonne University, La Pitié Salpêtrière Hospital, Paris, France.
Department of Anesthesiology and Critical Care, AP-HP, Sorbonne University, La Pitié Salpêtrière Hospital, Paris, France.
Department of Internal Medicine 2, AP-HP, Sorbonne University, La Pitié-Salpêtrière Hospital, Paris, France.
INSERM, UMRS 1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France.

Brain biopsy is a useful surgical procedure in the management of patients with suspected neoplastic lesions. Its role in neurologic diseases of unknown etiology remains controversial, especially in ICU patients. This study was undertaken to determine the feasibility, safety, and the diagnostic yield of brain biopsy in critically ill patients with neurologic diseases of unknown etiology. We also aimed to compare these endpoints to those of non-ICU patients who underwent a brain biopsy in the same clinical context.

中文翻译：

重症患者病因不明的神经系统疾病的脑活检：可行性、安全性和诊断率。

脑活检是治疗疑似肿瘤病变患者的一种有用的外科手术。它在病因不明的神经系统疾病中的作用仍然存在争议，特别是在 ICU 患者中。本研究旨在确定对患有不明原因神经系统疾病的危重患者进行脑活检的可行性、安全性和诊断率。我们还旨在将这些终点与在相同临床背景下接受脑活检的非 ICU 患者的终点进行比较。

更新日期：2022-01-10

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