Since diabetes was first described over 3,000 years ago, clinicians and scientists alike have sought ever improving treatments en route to a cure. As we approach the 100th anniversary of insulin’s first therapeutic use, this article will recount the glorious history associated with research surrounding insulin’s isolation, purification, cloning, and subsequent modification. The discovery path we will relate tells the story of many relentless and passionate investigators pursuing ground-breaking research. The fruits of their labor include several Nobel Prizes, new technology, and, more importantly, ever improving treatments for one of humankind’s greatest medical scourges.

中文翻译：

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现代医学中以胰岛素为重点的研究发挥着崇高且常常是诺贝尔奖的作用

自从 3000 多年前首次描述糖尿病以来，临床医生和科学家都在寻求不断改进的治疗方法以达到治愈的目的。在胰岛素首次用于治疗用途 100 周年之际，本文将回顾与胰岛素分离、纯化、克隆和后续修饰研究相关的辉煌历史。我们将讲述的发现之路讲述了许多不懈而热情的研究人员追求突破性研究的故事。他们的劳动成果包括多项诺贝尔奖、新技术，更重要的是，不断改进针对人类最大的医学祸害之一的治疗方法。