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Long-term association of pregnancy and maternal brain structure: the Rotterdam Study
European Journal of Epidemiology ( IF 13.6 ) Pub Date : 2022-01-06 , DOI: 10.1007/s10654-021-00818-5
Jurate Aleknaviciute 1 , Tavia E Evans 2, 3 , Elif Aribas 4 , Merel W de Vries 1 , Eric A P Steegers 5 , Mohammad Arfan Ikram 4 , Henning Tiemeier 6, 7 , Maryam Kavousi 4 , Meike W Vernooij 3, 4 , Steven A Kushner 1
Affiliation  

The peripartum period is the highest risk interval for the onset or exacerbation of psychiatric illness in women’s lives. Notably, pregnancy and childbirth have been associated with short-term structural and functional changes in the maternal human brain. Yet the long-term effects of pregnancy on maternal brain structure remain unknown. We investigated a large population-based cohort to examine the association between parity and brain structure. In total, 2,835 women (mean age 65.2 years; all free from dementia, stroke, and cortical brain infarcts) from the Rotterdam Study underwent magnetic resonance imaging (1.5 T) between 2005 and 2015. Associations of parity with global and lobar brain tissue volumes, white matter microstructure, and markers of vascular brain disease were examined using regression models. We found that parity was associated with a larger global gray matter volume (β = 0.14, 95% CI = 0.09–0.19), a finding that persisted following adjustment for sociodemographic factors. A non-significant dose-dependent relationship was observed between a higher number of childbirths and larger gray matter volume. The gray matter volume association with parity was globally proportional across lobes. No associations were found regarding white matter volume or integrity, nor with markers of cerebral small vessel disease. The current findings suggest that pregnancy and childbirth are associated with robust long-term changes in brain structure involving a larger global gray matter volume that persists for decades. Future studies are warranted to further investigate the mechanism and physiological relevance of these differences in brain morphology.



中文翻译:

妊娠与母体大脑结构的长期关联:鹿特丹研究

围产期是女性一生中精神疾病发作或恶化的最高风险区间。值得注意的是,怀孕和分娩与母体人类大脑的短期结构和功能变化有关。然而,怀孕对母体大脑结构的长期影响仍然未知。我们调查了一个基于人群的大型队列,以检查胎次与大脑结构之间的关联。2005 年至 2015 年间,共有 2,835 名来自鹿特丹研究的女性(平均年龄 65.2 岁;均未患痴呆、中风和脑皮质梗死)接受了磁共振成像 (1.5 T)。产次与全球和脑叶组织体积的关联、白质微结构和血管性脑疾病的标志物使用回归模型进行了检查。我们发现平价与更大的全球灰质体积相关(β = 0.14, 95% CI = 0.09-0.19),这一发现在调整社会人口因素后仍然存在。在较高的分娩次数和较大的灰质体积之间观察到不显着的剂量依赖性关系。灰质体积与平价的关联在肺叶之间呈全球比例。没有发现与白质体积或完整性有关,也没有发现与脑小血管疾病标志物有关。目前的研究结果表明,怀孕和分娩与大脑结构的强烈长期变化有关,涉及持续数十年的更大的全球灰质体积。未来的研究有必要进一步研究这些大脑形态差异的机制和生理相关性。

更新日期:2022-01-06
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