Salmonella enterica subsp. enterica serovar Schwarzengrund (S. Schwarzengrund) is most frequently isolated from commensals humans or poultry. Here we report S. Schwarzengrund strain S16, the first sequenced genome in the Republic of Korea. Additionally, genome sequencing for strain S16 was performed and compared with other S. Schwarzengrund genomes obtained from public database. Strain S16 was isolated from chicken feces. The complete genome consists of one chromosome and one plasmid. The genome size is 4,822,755 bp with 4852 coding sequences. Strain S16 was determined as serovar Schwarzengrund by in silico serotyping and typed as sequence type (ST) 96. Forty-six S. Schwarzengrund genomes yielded a pangenome of 7112 genes, core-genome of 3374 genes, accessory-genome of 2906 genes, and unique-genome of 835 genes. Eighty-one genes were unique to strain S16, including hypothetical proteins and transcriptional regulators. Genotypic analysis of antibiotic resistance of strain S16 confirmed resistance to amikacin, ciprofloxacin, sulfamethoxazole, streptomycin, and tetracycline. Unlike other S. Schwarzengrund genomes, strain S16 had a mutation of gyrB. Moreover, similar to other S. Schwarzengrund genomes reported in other countries, strain S16 was harbored for 153 virulence genes including Saf operon and cdtB gene. All the antibiotic resistance genes and virulence genes were present in the core- or accessory-genomes. Complete genome of strain S16 was sequenced. Comparative genomic analysis revealed several genes responsible for antibiotic resistance and specific genomic features of strain S16 and identified virulence factors that might contribute to the human and animal pathogenicity of other S. Schwarzengrund genomes.

中文翻译：

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肠道沙门氏菌亚种的基因组特征和比较基因组学。从鸡粪便中分离出的肠杆菌血清型 Schwarzengrund S16

肠沙门氏菌亚种。enterica serovar Schwarzengrund (S. Schwarzengrund) 最常从共生的人类或家禽中分离出来。在这里，我们报告 S. Schwarzengrund 菌株 S16，这是韩国第一个测序的基因组。此外，对 S16 菌株进行基因组测序，并与从公共数据库获得的其他 S. Schwarzengrund 基因组进行比较。从鸡粪中分离出菌株 S16。完整的基因组由一个染色体和一个质粒组成。基因组大小为 4,822,755 bp，包含 4852 个编码序列。菌株 S16 通过计算机血清分型确定为血清型 Schwarzengrund，并分型为序列类型 (ST) 96。46 个 S. Schwarzengrund 基因组产生了 7112 个基因的泛基因组、3374 个基因的核心基因组、2906 个基因的辅助基因组和835个基因的独特基因组。81 个基因是 S16 菌株独有的，包括假设的蛋白质和转录调节因子。对 S16 菌株的抗生素耐药性的基因型分析证实了对阿米卡星、环丙沙星、磺胺甲恶唑、链霉素和四环素的耐药性。与其他 S. Schwarzengrund 基因组不同，S16 菌株具有 gyrB 突变。此外，与其他国家报道的其他 S. Schwarzengrund 基因组相似，菌株 S16 含有 153 个毒力基因，包括 Saf 操纵子和 cdtB 基因。所有抗生素抗性基因和毒力基因都存在于核心或辅助基因组中。对菌株 S16 的完整基因组进行了测序。