Healthcare and outcomes for children with medical complexity (CMC) and their families can be improved by conducting well-conceived, designed, implemented, and analyzed research studies of clinical interventions. This article presents a framework for how to approach the study of clinical interventions for CMC, including 7 key questions and example answers to each: (1) What intervention questions should be our focus? (2) What barriers to intervention research exist? (3) How do we design and optimize interventions? (4) How do we characterize and select patients to enroll? (5) How can we enhance data collection and integration? (6) How can we improve enrollment and participation? And (7) which intervention experimental designs should we choose? By exploring each of these key aspects of intervention-based research, we hope to expand thinking about and spark ideas for specific research projects focused on clinical interventions for CMC.

通过对临床干预进行精心构思、设计、实施和分析的研究，可以改善患有医学复杂性 (CMC) 的儿童及其家庭的医疗保健和结果。本文介绍了如何处理 CMC 临床干预研究的框架，包括 7 个关键问题和每个问题的示例答案：(1) 我们应该关注哪些干预问题？(2) 干预研究存在哪些障碍？(3) 我们如何设计和优化干预措施？(4) 我们如何描述和选择患者入组？(5) 如何加强数据收集和整合？(6) 我们如何提高入学率和参与度？以及（7）我们应该选择哪些干预实验设计？通过探索基于干预的研究的每个关键方面，