How distal cis-regulatory elements (e.g., enhancers) communicate with promoters remains an unresolved question of fundamental importance. Although transcription factors and cofactors are known to mediate this communication, the mechanism by which diffusible molecules relay regulatory information from one position to another along the chromosome is a biophysical puzzle—one that needs to be revisited in light of recent data that cannot easily fit into previous solutions. Here we propose a new model that diverges from the textbook enhancer–promoter looping paradigm and offer a synthesis of the literature to make a case for its plausibility, focusing on the coactivator p300.

中文翻译：

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转录因子活性梯度（TAG）模型：考虑增强子-启动子通信的独立于接触的机制

远端顺式调节元件（例如，增强子）如何与启动子通信仍然是一个未解决的根本问题。尽管已知转录因子和辅助因子可以介导这种交流，但可扩散分子沿染色体将调控信息从一个位置传递到另一个位置的机制是一个生物物理学难题——需要根据最近的数据重新审视，这些数据不容易适应以前的解决方案。在这里，我们提出了一个不同于教科书增强子-启动子循环范式的新模型，并提供了文献综合以证明其合理性，重点关注辅激活子 p300。