Arifa Areej Farooqui^1,*; A B Tarun Kumar²; Rucha Shah¹; Triveni M G¹

¹Department of Periodontics, Bapuji Dental College and Hospital; ²Bapuji Implant Centre, Bapuji Dental College & Hospital, Karnataka, India

Background: Peri-implant keratinized mucosa (KM) is of great significance in the long term maintenance of restorations. Free gingival grafts (FGG) are considered as gold standard but have the limitations of poor color match and increased morbidity. A combination of FGG strip with xenogenic collagen matrix (XCM) was recently introduced showing favorable results in augmentation of KM with the advantages of reduced morbidity and better color match.

Aim/Hypothesis: To evaluate and compare the gain in peri-implant keratinized mucosa using a combination of FGG strip with XCM to that of FGG alone.

Material and Methods: In this randomized controlled clinical study, a total of 30 patients were included having minimal amount of peri-implant KM (≤1 mm). The study population was divided into 2 groups by randomization protocol; Group A (n = 15) received a combination of FGG strip and XCM and Group B (n = 15) received FGG only to augment KM. All the surgical procedures were carried out by a single operator by using a combination of FGG strip +XCM or FGG alone. Clinical parameters include width of keratinized mucosa (WKM) measured at baseline, 1 month and 6 months, pink esthetic score (PES) measured at baseline and 6 months and patient morbidity using visual analog scale (VAS) at day 1, day 7 and day 14.

Results: All the data was tabulated and analyzed using various parametric and non -parametric tests. . At 6 months both groups showed statistically significant gain in WKM when compared from baseline (p < 0.05). However this gain was found to be statistically non-significant when compared between the two groups at all time intervals, that is, at baseline, 1 month and 6 months (p > 0.05). On the other hand statistically significant difference was found between the two groups when the data of PES and VAS was compared (p < 0.05).

Conclusion and Clinical implications: The preliminary data obtained from this study indicates that the combination of FGG strip and XCM is a viable and predictable alternative in augmenting peri-implant keratinized mucosa with minimal morbidity and better esthetic outcomes when compared to the FGG which is considered as gold standard. However, long term studies with larger sample size are needed to confirm the results obtained in the present study to further validate this surgical procedure.

Disclosure of Interest: None Declared

Keywords: biomaterial, clinical studies/trials, peri-implantitis

Arifa Areej Farooqui ^1,* ; AB 塔伦库马尔² ; 鲁查沙¹ ; 特里维尼 MG ¹

¹八普济口腔医院牙周病科；² Bapuji 种植中心，Bapuji 牙科学院和医院，印度卡纳塔克邦

背景：种植体周围角化黏膜 (KM) 在修复体的长期维护中具有重要意义。游离牙龈移植物 (FGG) 被认为是金标准，但存在颜色匹配差和发病率增加的局限性。最近引入了 FGG 条带与异种胶原基质 (XCM) 的组合，显示出增加 KM 的有利结果，具有降低发病率和更好的颜色匹配的优点。

目的/假设：评估和比较使用 FGG 条与 XCM 的组合与单独使用 FGG 的种植体周围角化粘膜的增益。

材料和方法：在这项随机对照临床研究中，共纳入了 30 名种植体周围 KM（≤1 毫米）的患者。研究人群通过随机化方案分为 2 组；A 组（n = 15）接受 FGG 条带和 XCM 的组合，B 组（n = 15）接受 FGG 只是为了增加 KM。所有手术过程均由一名操作者通过使用FGG条+XCM或单独使用FGG的组合进行。临床参数包括在基线、第 1 个月和第 6 个月测量的角化黏膜宽度 (WKM)、在基线和第 6 个月测量的粉红色美学评分 (PES) 以及在第 1、第 7 天和第 1 天使用视觉模拟量表 (VAS) 测量的患者发病率14.

结果：使用各种参数和非参数检验对所有数据进行制表和分析。. 在 6 个月时，与基线相比，两组的 WKM 都有统计学意义的增加 ( p < 0.05)。然而，当在所有时间间隔，即在基线、1 个月和 6 个月时，在两组之间进行比较时，发现这种增益在统计学上不显着（p > 0.05）。另一方面，当比较PES和VAS的数据时，发现两组之间存在统计学上的显着差异（p < 0.05）。

结论和临床意义：从这项研究中获得的初步数据表明，与 FGG 相比，FGG 条和 XCM 的组合是一种可行且可预测的替代方法，可增加种植体周围角化黏膜的发病率和更好的美学效果，FGG 被认为是黄金标准。然而，需要更大样本量的长期研究来证实本研究中获得的结果，以进一步验证这种外科手术。

利益披露：无申报

关键词：生物材料，临床研究/试验，种植体周围炎