Ultrasensitive and affordable assay for early detection of primary liver cancer using plasma cell-free DNA fragmentomics,Hepatology

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Ultrasensitive and affordable assay for early detection of primary liver cancer using plasma cell-free DNA fragmentomics
Hepatology ( IF 13.5 ) Pub Date : 2021-12-25 , DOI: 10.1002/hep.32308
Xiangyu Zhang _{1,

2,

3} , Zheng Wang _{1,

2,

3} , Wanxiangfu Tang ₄ , Xinyu Wang _{1,

2,

3} , Rui Liu ₄ , Hua Bao ₄ , Xin Chen ₄ , Yulin Wei ₄ , Shuyu Wu ₄ , Hairong Bao ₄ , Xue Wu ₄ , Yang Shao ₄ , Jia Fan _{1,

2,

3,

5,

6} , Jian Zhou _{1,

2,

3,

5,

6}

Affiliation

Early detection of primary liver cancer (PLC), including HCC, intrahepatic cholangiocarcinoma (ICC), and combined HCC-ICC (cHCC-ICC), is essential for patients’ survival. This study aims to develop an accurate and affordable method for PLC early detection and differentiating ICC from HCC using plasma cell-free DNA (cfDNA) fragmentomic profiles.

中文翻译：

使用无浆细胞 DNA 片段组学早期检测原发性肝癌的超灵敏且经济实惠的检测方法

早期发现原发性肝癌 (PLC)，包括 HCC、肝内胆管癌 (ICC) 和联合 HCC-ICC (cHCC-ICC)，对于患者的生存至关重要。本研究旨在开发一种准确且经济实惠的 PLC 早期检测方法，并使用浆细胞游离 DNA (cfDNA) 片段组图谱将 ICC 与 HCC 区分开来。

更新日期：2021-12-25

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