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Michael addition mediated domino cyclization of hydrazide embedded pyrazolyl derivatives: Biological and its molecular docking examinations
Indian Journal of Chemical Technology ( IF 0.5 ) Pub Date : 2021-12-24
Sarangapani Muniraj, Ganesan Suresh

An easing and efficiently synthesized biologically and pharmacologically active quinolinyl- tethered pyrazoline molecules in the presence of chalcones, have been obtained from condensation of corresponding aldehydes and ketones, through concomitant utilization of aryl hydrazide as useful starting substrates underwent Michael-addition followed by domino cyclization. The final products have been obtained in excellent yields, and they have been well characterized using FTIR, 1H, 13C NMR and mass spectral analyses. Moreover, all the newly synthesized molecules have been examined for the antimicrobial and anticancer activities by MTT assay as well as molecular docking studies.

中文翻译:

迈克尔加成介导的酰肼嵌入吡唑基衍生物的多米诺环化:生物学及其分子对接检查

在查耳酮的存在下,通过将芳基酰肼作为有用的起始底物进行迈克尔加成,然后进行多米诺环化,相应的醛和酮缩合得到了一种简便且有效合成的生物和药理活性喹啉基系吡唑啉分子。最终产品的收率非常好,并且已经使用 FTIR、1H、13C NMR 和质谱分析对其进行了很好的表征。此外,所有新合成的分子都已通过 MTT 测定以及分子对接研究检查了抗微生物和抗癌活性。
更新日期:2021-12-24
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