Purpose: This study evaluated the effects of 12 weeks of karate training on cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Method: Seventy adolescents were randomized into 2 groups: control received nutritional and psychological interventions once a week for 12 weeks, and treatment received nutritional and psychological interventions once a week, plus 3 karate sessions per week, for 12 weeks. The main outcome measure was improvement in cardiometabolic parameters, oxidative stress, and inflammation. Results: After the intervention period, the treatment group showed a reduction in resting heart rate (77.86 [10.89]), high-density lipoprotein cholesterol (40.86 [8.31]), and triglycerides (75.18 [32.29]) and an increase in low-density lipoprotein cholesterol (95.64 [42.53]) in relation to pretraining. Regarding oxidative stress markers, there was a reduction in protein carbonylation (0.07 [0.06]) and nitric oxide (1.39 [1.11]) and an increase in superoxide dismutase (0.68 [0.31]) and glutathione (0.11 [0.08]) compared with pretraining. With respect to inflammation, adiponectin increased (14.54 [5.36]) after the intervention when compared with preintervention. Conclusion: The study concluded that the intervention may improve cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Long-term effects need to be evaluated.

目的：本研究评估了 12 周的空手道训练对超重和肥胖青少年的心脏代谢参数、氧化应激和炎症的影响。方法： 70 名青少年随机分为 2 组：对照组每周接受一次营养和心理干预，持续 12 周，治疗组每周接受一次营养和心理干预，外加每周 3 次空手道训练，持续 12 周。主要结果衡量指标是心脏代谢参数、氧化应激和炎症的改善。结果：干预期结束后，治疗组静息心率（77.86 [10.89]）、高密度脂蛋白胆固醇（40.86 [8.31]）和甘油三酯（75.18 [32.29]）降低，低密度脂蛋白升高与预训练相关的胆固醇（95.64 [42.53]）。关于氧化应激标志物，与训练前相比，蛋白质羰基化 (0.07 [0.06]) 和一氧化氮 (1.39 [1.11]) 减少，超氧化物歧化酶 (0.68 [0.31]) 和谷胱甘肽 (0.11 [0.08]) 增加. 在炎症方面，与干预前相比，干预后脂联素增加（14.54 [5.36]）。结论：该研究得出结论，干预可能会改善超重和肥胖青少年的心脏代谢参数、氧化应激和炎症。需要评估长期影响。